Charting A Pathway To Better Health

Long-term ventilation: charting a pathway home.

Children with chronic respiratory insufficiency who require assisted ventilation are a very complex and vulnerable cohort within the growing spectrum of children with physical and developmental disabilities. Beginning in the late 1970s, technological innovation and a growing appreciation of the broader social contributions of children and adults with disabilities, facilitated the transition of ...

Advancing Health Literacy Measurement: A Pathway to Better Health and Health System Performance

The concept of health literacy initially emerged and continues to gain strength as an approach to improving health status and the performance of health systems. Numerous studies clearly link low levels of education, literacy, and health literacy with poor health, poor health care utilization, increased barriers to care, and early death. However, theoretical understandings and methods of measuri...

Charting the NF-κB Pathway Interactome Map

Inflammation is part of a complex physiological response to harmful stimuli and pathogenic stress. The five components of the Nuclear Factor κB (NF-κB) family are prominent mediators of inflammation, acting as key transcriptional regulators of hundreds of genes. Several signaling pathways activated by diverse stimuli converge on NF-κB activation, resulting in a regulatory system characterized b...

Charting the Secretory Pathway in a Simple Eukaryote

George Palade, a founding father of cell biology and of the American Society for Cell Biology (ASCB), established the ultrastructural framework for an analysis of how proteins are secreted and membranes are assembled in eukaryotic cells. His vision inspired a generation of investigators to probe the molecular mechanisms of protein transport. My laboratory has dissected these pathways with compl...

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